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September 8th, 2010 – After more than 4,400 episodes and 28,000 guests, “The Oprah Winfrey Show” launches its farewell season on Monday, September 13. Highlights of the new season’s premiere week episodes include:

Monday, September 13
The top-secret 25th season premiere will feature special appearances by celebrity guests and a surprise musical performance. Plus, dreams will come true for some lucky “Oprah” show viewers.

Tuesday, September 14
Grammy Award-winning country music legends The Judds return to the “Oprah” show stage. During the hour, Naomi and Wynonna discuss plans for their upcoming farewell tour, “The Last Encore,” give a private tour of the 1,000-acre Tennessee farm they call home, and perform a special duet for Oprah. Plus, Wynonna speaks out about how she’s lost more than 60 pounds, and opens up about how she survived the ordeal of her former husband’s arrest and conviction.

Wednesday, September 15
Oprah revisits one of her most memorable shows when she returns to Williamson, West Virginia, the site of a town hall episode on AIDS on November 16, 1987. After Michael Sisco, a town resident who had contracted AIDS, swam in the local swimming pool, the mayor shut down the facility, sparking a community-wide debate. The emotional hour featured heated exchanges between Sisco and his neighbors, as fears spread in the early days of the AIDS epidemic. Now, close to 23 years later, Oprah returns to the Williamson Field House, site of the original show, for a candid discussion with Sisco’s family members and other guests from the 1987 episode.

Thursday, September 16
Oprah talks with people making headlines around the world, including 28-year-old Bethany Storro, who was scarred in a brutal acid attack by a stranger August 30 in Vancouver, Washington. Storro will appear in-studio for her first one-on-one interview since being released from the hospital.

Friday, September 17
Closing out premiere week is an episode jam-packed with surprises galore. Plus, exactly 14 years to the day since launching her Book Club, Oprah makes a live announcement of her 64th Oprah’s Book Club selection.

About “The Oprah Winfrey Show”
"The Oprah Winfrey Show" has remained the number one talk show for 24 consecutive seasons, winning every sweep since its debut in 1986.* It is produced in Chicago by Harpo Productions, Inc. and syndicated to 215 domestic stations by CBS Television Distribution and to 145 countries by CBS Studios International.

*Nielsen Cassandra Ranking Report - Nov '86 to May '99 and Wrap Sweeps, Nov '99 to May '10, major sweeps only. Wtd Avg DMA HH Rtg, Primary Telecasts Only.